High concordance between EGFR mutations from circulating-free tumor DNA and tumor tissue in non-small cell lung cancer.
DENVER – Epidermal growth factor receptor (EGFR) mutations found in the circulating free tumor DNA (ctDNA) from the plasma of advanced non-small cell lung cancer (NSCLC) patients correlates well with the EGFR mutations from patient-matched tumor tissue DNA.
DENVER – For the first time an oncogenic somatic mutation at amino acid 918 in the RET (rearranged during transfection) protein has been identified in small cell lung cancer (SCLC) tumors and enforced expression of this mutation within SCLC cell lines produced increased intracellular signaling and cell growth.
The International Association for the Study of Lung Cancer mourns the loss of Jesse L. Steinfeld, MD, the 11th Surgeon General of the United States (1969-1973), who passed away on August 5, 2014 in Pomona, CA at the age of 87.
The Journal of Thoracic Oncology (JTO) for 2013 has increased its impact factor from 4.47 in 2012 to 5.8. This makes JTO the 26th oncology journal and 5th in respiratory journals out of 202 and 53 journals respectively.
Increased overall survival for advanced stage NSCLC patients is associated with availability of less toxic chemotherapy.
DENVER – A 10-year population-based study shows that increased availability of better systemic chemo- and targeted-therapies for patients with advanced non-small cell lung cancer (NSCLC) coincides with increased usage of these therapies. This in turn leads to a significant increase in overall survival.
ROS1 gene fusions are found in 2.4% of Asian patients with lung adenocarcinoma and are associated with young age at diagnosis.
DENVER – ROS1 fusion genes were successfully detected independent of gender or smoking history in young East Asian patients with lung adenocarcinoma, a histological subgroup in non-small cell lung cancer (NSCLC), using multiplex reverse transcriptase-polymerase chain reaction (RT-PCR) and immunohistochemistry (IHC) diagnostic tests.