Research & Education

Modest acute changes in cardiac biomarkers and electrocardiogram findings following thoracic radiation therapy.

DENVER – There were only modest acute changes in cardiac biomarkers and electrocardiograms and there were no clinically significant cardiac events in patients with high-dose radiation exposure to the heart following thoracic radiation therapy (RT) and short-term follow-up.

Abstracts for LALCA 2014 now published in the JTO.

DENVER – The International Association for the Study of Lung Cancer (IASLC) is pleased to announce that scientific abstracts for the 6th Latin American Conference on Lung Cancer (LALCA) are now available online through the Journal of Thoracic Oncology.

BIM deletion predicts survival in advanced non-small cell lung cancer.

DENVER – Bcl-2-like protein 11 (BIM) deletion in advanced non-small cell lung cancer (NSCLC) is associated with shorter progression free survival (PFS) in epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) or chemotherapy treated Asian patients. Also, BIM deletion independently predicts overall survival (OS) of advanced NSCLC patients.

High concordance between EGFR mutations from circulating-free tumor DNA and tumor tissue in non-small cell lung cancer.

DENVER – Epidermal growth factor receptor (EGFR) mutations found in the circulating free tumor DNA (ctDNA) from the plasma of advanced non-small cell lung cancer (NSCLC) patients correlates well with the EGFR mutations from patient-matched tumor tissue DNA.

Novel oncogenic RET mutation found in small cell lung cancer.

DENVER – For the first time an oncogenic somatic mutation at amino acid 918 in the RET (rearranged during transfection) protein has been identified in small cell lung cancer (SCLC) tumors and enforced expression of this mutation within SCLC cell lines produced increased intracellular signaling and cell growth.

Jesse Leonard Steinfeld, MD

The International Association for the Study of Lung Cancer mourns the loss of Jesse L. Steinfeld, MD, the 11th Surgeon General of the United States (1969-1973), who passed away on August 5, 2014 in Pomona, CA at the age of 87.

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