Targeted next-generation sequencing reveals a high number of genomic mutations in advanced malignant plural mesothelioma.
DENVER – Next generation sequencing in malignant pleural mesothelioma (MPM) tumors shows a complex mutational setting with a high number of genetic alterations in genes involved in DNA repair, cell survival and cell proliferation pathways. Increased accumulation of mutations correlates with early progression of the tumor and decreased survival.
DENVER – The International Association for the Study of Lung Cancer (IASLC) is pleased that the Centers for Medicare & Medicaid Services (CMS) made a draft proposal Monday to cover low-dose CT screening of patients at high risk for lung cancer.
Interstitial lung disease is a significant risk factor for lung inflammation following stereotactic body radiation therapy for lung cancer.
DENVER – Pretreatment interstitial lung disease (ILD) is a significant risk factor for developing symptomatic and severe radiation pneumonitis in stage I non-small cell lung cancer (NSCLC) patients treated with stereotactic body radiation therapy (SBRT) alone.
DENVER – A risk stratification model based on lymph node characteristics confirms with a high level of confidence the true lack of lung cancer in lymph nodes adequately sampled with endobronchial ultrasound-guided transbronchial needle aspiration and classified as negative.
DENVER – A better survival outcome is associated with low blood levels of squamous cell carcinoma antigen, or absence of tumor invasion either into the space between the lungs and chest wall or into blood vessels of individuals with a peripheral squamous cell carcinoma, a type of non-small cell lung cancer (NSCLC).
Novel software application can stratify early-stage non-small cell lung cancer patients into risk categories based on analysis of computed tomography images.
DENVER –CANARY, Computer-Aided Nodule Assessment and Risk Yield, is a novel software tool developed at Mayo Clinic that can automatically quantitate adenocarcinoma pulmonary nodule characteristics from non-invasive high resolution computed tomography (HRCT) images and stratify non-small cell lung cancer (NSCLC) patients into risk groups that have significantly different disease-free survival outcome