Medical Oncology

Lung Cancer Control and Epidemiology

Tobacco Control and Primary Prevention
  1. Magnitude of the tobacco epidemic world wide

  2. Global efforts to curb use of tobacco products

  3. Possible impact of these efforts on mortality from lung cancer
Tobacco Cessation
  1. Overview about how lung cancer specialists should help their patients stop tobacco use
  2. Describe mechanisms about how persistent tobacco use affects cancer treatment
  3. Provide information about how to help patients stop tobacco use
Non-Smoking Related Lung Cancer
  1. Postulated mechanisms for non-smoking related lung cancer
  2. Magnitude of the problem world-wide
  3. Variance with ethnicity and geography


Clinical and Radiologic Presentation of Lung Cancer

Clinical Presentation
  1. Symptoms and signs of non small cell lung cancer

  2. Symptoms and signs of small cell lung cancer
Describe paraneoplastic and other syndromes associated with NSCLC
  4. Clinical, pathological and molecular diagnostic algorithms for lung cancer
Lung Cancer Staging
  1. Rationale for staging investigations
  2. AJCC stage 6 vs 7


Surgical Management of Lung Cancer

Results of Video Assisted Techniques for Resection of Lung Cancer
  1. Definitions of VATS surgery for lung cancer, specifically pulmonary resections and different varieties of VATS

  2. How does it compare to standard resection both acute and late
  3. What are the benefits and the limitations?
Evidence-based/meta/summary analyses of VATS vs Non-VATS


Radiotherapeutic Management of Lung Cancer

Management of Stage III NSCLC
  1. Mediastinal staging
  2. Medical considerations for radical chemoradiotherapy
  3. Optimal combined modality treatment appraoches
Palliative Radiotherapy for Lung Cancer: Locoregional and Metastatic
  1. Indications for palliative radiotherapy (thorax, brain, bone, other).
  2. Dose, fractionation. Role in combination with other treatments (surgery, chemotherapy).
  3. Outcomes - symptom control, quality of life
Acute and Late Toxicities of Thoracic Radiotherapy: Pulmonary, Esophagus, Heart
  1. Pulmonary and heart
  2. Esophagus

  3. Quality of life


Chemotherapy and Targeted Agents for Lung Cancer

Metastatic NSCLC: Optimal management
  1. Discussion of molecular tests which have clinical relevance and impact on first line treatment choices
    1. Discuss methods for obtaining material for testing and requirements, as well as diagnostic criteria
    2. Discuss the problems and advantages of platforms used to do these molecular tests

  2. Choice of cytotoxic chemotherapy based on histology subtype
  3. Landmark studies in metastatic EGFR and ALK positive NSCLC
  4. Outcomes: symptom control, adverse events, survival
  5. Potential new therapeutically targetable alterations (e.g. BRAF, PIK3CA alterations)
Maintenance Therapy in NSCLC
  1. Concept of maintenance
  2. Old studies testing the concept
  3. Switch maintenance vs. continuation maintenance
  4. Review of recent randomized studies
  5. Meta-analyses
  6. Which drug and which patients?
Immunotherapy and Lung Cancer
  1. Immunological dysfunction in lung cancer
  2. Review of the supportive evidence for immunotherapy in lung cancer
  3. Review of agents and clinical studies
Management of Toxicities of Targeted Therapies
  1. Toxicities associated with novel therapies in lung cancer
  2. Preventive measures and treatment
  3. Discussion of Ethnic variations
Systemic Therapy in Early-Stage NSCLC
  1. Supportive evidence for neoadjuvant and adjuvant chemotherapy in completely resected NSCLC
  2. Chemotherapy regimens: indications, adverse events
  3. Meta-analysis of adjuvant trials


Other Thoracic Malignancies

Malignant Mesothelioma
  1. Biology of pleural mesothelioma
  2. Biomarkers
  5. Multimodality
  6. New therapies
Mediastinal Tumors
  1. Thymic malignancies – thymoma and thymic carcinoma
  2. Surgical management radiotherapy and chemotherapy management
Neuroendocrine Tumors of the Lung Other than SCLC
  1. Diagnosis
  2. Surgical management
Chemotherapy and targeted agents


Symptom Management and Complications

Role of Palliative Care in Lung Cancer
  1. Describe when palliative care should be used
Describe studies documenting the benefits of palliative care
  3. Discuss the individual components of palliative care
Discuss end of life issues


Clinical Trials

Methodology of Clinical Trials in Lung Cancer
  1. Endpoints and patient selection: Maintenace trials, targeted therapies
  2. Design consideratiosn for phase II, phase III and phase II/III
  3. Principles of pooled analysis to evaluate alternate endpoints


Translational Research

  1. Review concept of pharmacogenomics in NSCLC
  2. Use of gene expression microarray in NSCLC
  3. Next generation sequencing studies in lung cancer (e.g. adenocarcinoma and squamous)
  4. Delineating primary resistance mechanisms in NSCLC: Value of re-biopsies in delineating evolving molecular subytpes