August 2014 Newsletter update

August 2014 Newsletter

Table of Contents

  President Corner
Tony Mok Photo
Tony S.K. Mok, IASLC President

Pleasant surprises awaited me at the end of an eighteen hours journey. It was home, a very lovely home. However, it was not my home but the home of IASLC. This is the first time in the history of our organization that the Board of Directors meeting took place at our home office. Not sure if I can find the right words to label my emotion when I saw the brilliant “IASLC” logo at the office entrance. This cozy office is actually the united front of scientists, doctors, nurses and patients in the war against lung cancer. This is the physical facility that represents our fighting spirit.

Another delight is our cohesive Board of Directors. Our Board is designed to cover a wide geographic and specialty representation. There are 5 members each representing North America, Europe and Rest of the World. Among us, we have surgeons, pathologists, respirologists, medical and radiation oncologists. The Board takes on key directional issues of the organization and we strive towards the betterment of our current services and education programs. Key decision during the August Board meeting in Denver included looking at opitions for a new publisher for JTO, endorsing the Pathology committee to start a PD-L1 project and selection of city for WCLC 2019. 

“Association” means a body of persons with common purpose. This is the “A” of IASLC and I have not doubt that our common purpose is to fight lung cancer.

Fred Hirsch
Fred R. Hirsch, IASLC Chief Executive Officer

Dear Colleagues,

Within the last month, many activities have occurred within IASLC. The Board of Directors had a meeting in Denver, Colorado for the first time in our Headquarters. All participants were impressed  with our new offices.

The Latin-American Lung Cancer Conference was last week held in Lima, Peru with 747 registrants - the largest LALCA meeting ever. Congratulations to the organizers led by the LALCA 2014 President, Prof Carlos Vallejos and Dr. Luis Raez. The scientific program was excellent with close to 200 abstract presentations. The next LALCA meeting will be held in 2016 in Panama with Prof Roberto ivan Lopez  as LALCA President and Dr. Edgardo Santos as Congress Secretary. Over the next years IASLC will work closely with the LALCA group to make educational activities in the region. During the Lima meeting IASLC also launched the Spanish version of our ALK- Atlas, which can be viewede through our website. We have now also finished a Japanese and a Chinese version, which can also be ordered by visiting Last, but not least, it is our hope that many IASLC members and other colleagues will subscribe to our new IASLC Multidisciplinary Approach to Thoracic Oncology!




 Registration and housing now open for the 2014 Chicago Multidisciplinary Symposium in Thoracic Oncology 
Members of the IASLC, American Society of Clinical Oncology, the American Society for Radiation Oncology, and the University of Chicago have designed an outstanding two-and-a-half day symposium.
October 30 - November 1 2014 | Chicago, Illinois | View Details




 Asian Pacific Lung Cancer Conference (APLCC)
The Asian Pacific Lung Cancer Conference will bring together medical professionals In Malaysia to discuss the latest in lung cancer research and treatment.
November 6 - 8 2014 | Malaysia | View Details




  The 1st Announcement is now available for the 16th World Conference on Lung Cancer in Denver, Colorado, USA September 6-9, 2015.
The 16th World Conference on Lung Cancer will be one of the largest international gatherings of multidisciplinary experts in the field of lung cancer and thoracic malignancies. Those interested in all aspects of lung cancer and thoracic malignancies including surgeons, medical oncologists, radiation oncologists, pulmonologists, radiologists, pathologists, epidemiologists, basic research scientists, nurses, allied-health professionals, and patient advocates are encouraged to attend this extraordinary conference. Read More

Radiation Therapy for Patients with Lung Cancer - Challenging Clinical Presentations

Monday September 1, 2014 8:00PM CST - MANDARIN LANGUAGE WEBINAR

 Advanced Radiation Therapy Live Webinar Series
September, and October 2014
The IASLC Education Committee is pleased to announce a series of Live Webinars presented by the Advanced Radiation Therapy (ART) Committee. More

All IASLC Meeting Information
To see the full schedule of IASLC Meetings, visit our event page.


The IASLC Multidisciplinary Approach to Thoracic Oncology
Do not miss out on your opportunity to have the premier educational resource on lung cancer at your fingertips. The book is available in soft-cover and digital access. The soft-cover is available for $225 (plus Shipping & Handling), digital subscription for $225 or get both for $300 (plus Shipping & Handling). Click Here to make your purchase.



Jesse Leonard Steinfeld, MD

The International Association for the Study of Lung Cancer mourns the loss of Jesse L. Steinfeld, MD, the 11th Surgeon General of the United States (1969-1973), who passed away on August 5, 2014 in Pomona, CA at the age of 87. Dr. Steinfeld was the first recipient of the Joseph W. Cullen Prevention and Early Detection Award from IASLC in 1994 at the 7th World Conference on Lung Cancer held in Colorado Springs, CO. The Joseph W. Cullen Prevention/Early Detection Award is given to an IASLC scientist for lifetime scientific achievements in prevention research of thoracic malignancies.
Aug 12 2014 | More


The Journal of Thoracic Oncology (JTO) for 2013 has increased its impact factor to 5.8

The Journal of Thoracic Oncology (JTO) for 2013 has increased its impact factor from 4.47 in 2012 to 5.8. This makes JTO the 26th oncology journal and 5th in respiratory journals out of 202 and 53 journals respectively.
Aug 1 2014 | More



The summer is quickly coming to an end and children are heading back to school. August has been a busy month for the IASLC office. IASLC main office now has a great looking sign above our doors at 13100 E. Colfax Ave in Aurora, CO. On the 16th  of August, IASLC hosted the Board of Directors meeting in our building, the first time the board has been together at the main office. The 6th Latin American Conference on Lung Cancer was held August 21 – 24 in Lima, Peru. On an exciting note, we will be launching our new IASLC member newsletter in September. So keep an eye out for that when it hits your inbox next month.



IASLC Pathology Committee
Professor Andrew G Nicholson, Chair

Currently, the IASLC Pathology Committee comprises 21 members representing 3 continents: North America (9 members), Europe (7 members) and Asia (5 members).  It is an active working group of like-minded individuals who produce guidelines and publications either for the IASLC alone or in conjunction with other organisations. Work is undertaken through various working parties that members are expected to join, based on their individual areas of expertise.

Since the World Conference on Lung Cancer (WCLC) in Sydney 2013, the committee has been primarily involved in two major projects. First, members have been collaborating with the International Agency for Research on Cancer (IARC) and the World Health Organization (WHO) as invited authors, in relation to the writing of the fourth edition of the WHO Classification of Tumours of the Lung, Pleura, Thymus and Heart, with three of the book editors being members of the current committee. Much of the discussion and consensus for the proposed structure came from IASLC Pathology Committee meetings, both those in 2013 and also a meeting held prior to the annual United States and Canadian Association of Pathologists (USCAP) meeting in San Diego at the end of February 2014. This has culminated in the successful submission of all chapters and images to the WHO, with a final meeting at the WHO/IARC headquarters in Lyon in April 2014, where the book was finalised. The book is due for publication in early 2015.

Alongside the WHO project, the committee have been working on a series of systematic reviews that follow on from the success of the updated proposal for classification of adenocarcinoma in 2011 (Travis et al. Journal of Thoracic Oncology 2011;6:244-85), a project sponsored by the IASLC, as well as the American Thoracic Society and European Respiratory Society. The committee met in December 2013 for a 3 day meeting at Memorial Sloan-Kettering Hospital in New York, with one day set aside for pathologists and the remainder a multidisciplinary meeting with oncologists, radiologists, surgeons, and molecular biologists. This created the basis for a series of systematic reviews in relation to major groupings of common lung tumours that are ongoing and will ideally serve as a template for informing the future direction of lung cancer classification.

The committee has also been active in validating proposed changes to lung cancer classification, either individually within host institutions or collectively in international studies relating to areas such as reproducibility of diagnosis. This work has produced two papers, the most recent on poorly differentiated squamous cell carcinomas currently in press in the Journal of Thoracic Oncology.

Finally, this year has seen the inception of a structured application process for the membership of the committee, which will provide a fair and robust process through which members become appointed on the basis of activity within the IASLC and national/international expertise in thoracic pathology, whilst ensuring a global representation within the committee itself. This process will run every two years, with rotation on and off the committee to coincide with WCLC meetings.


Highlighted JTO Articles


BIM deletion predicts survival in advanced non-small cell lung cancer.

DENVER – Bcl-2-like protein 11 (BIM) deletion in advanced non-small cell lung cancer (NSCLC) is associated with shorter progression free survival (PFS) in epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) or chemotherapy treated Asian patients. Also, BIM deletion independently predicts overall survival (OS) of advanced NSCLC patients. Aug 22 2014 | More

High concordance between EGFR mutations from circulating-free tumor DNA and tumor tissue in non-small cell lung cancer.

DENVER – Epidermal growth factor receptor (EGFR) mutations found in the circulating free tumor DNA (ctDNA) from the plasma of advanced non-small cell lung cancer (NSCLC) patients correlates well with the EGFR mutations from patient-matched tumor tissue DNA. Aug 22 2014 | More

Novel oncogenic RET mutation found in small cell lung cancer.

DENVER – For the first time an oncogenic somatic mutation at amino acid 918 in the RET (rearranged during transfection) protein has been identified in small cell lung cancer (SCLC) tumors and enforced expression of this mutation within SCLC cell lines produced increased intracellular signaling and cell growth. Aug 22 2014 | More



Member Feedback Requested – IASLC 2014 Membership Survey Launches in September
Thank you for being a member of IASLC! To help evaluate the needs of IASLC’s growing membership, IASLC seeks feedback annually on membership benefits, programs, and services.  The 2014 Member Feedback Survey will be distributed in late September 2014 and will be distributed to all active members.  The anonymous survey will take members no longer than 5 minutes to complete. 

Invite a Fellow for FREE IASLC Membership
You may already be aware that the IASLC offers FREE membership to fellows, but we want to make sure that more trainees around the world in multiple specialties are taking advantage of membership. Because of the importance of young investigators to the future of lung cancer research, fellows, residents and trainees may apply for free, non-voting membership by submitting a signed letter stating the term dates of their fellowship, residency or proof of trainee status from their department. 
Fellows, residents and trainees from all specialties are encouraged to join, including those from nursing and other allied health professions. Fellow membership is available for a maximum of two years. Fellows are non-voting members, entitled to many other IASLC benefits including online access to the Journal of Thoracic Oncology (JTO). 
Please invite a Fellow, Resident or Trainee today!
Member News
Are you active in Social Media?
Social media can be a powerful influence in the lives of those who use it. This is true for those affected by lung cancer.  Social media is trending to be a major communication tool for those seeking answers and support in the care for themselves or a loved one. IASLC encourages the use of social to support the mission of the IASLC. The Communication Committee is seeking members to volunteer help in developing and implementing the strategic communication plan via social media. If you are interested please use the online form to self-nominate for the position.  If you have questions, please don't hesitate to contact Rob Mansheim, Director of Communications, at We look forward to the global conversation on lung cancer through social media.

IASLC MEMBERS: If you have a newsworthy item or career change you would like featured, please email Rob Mansheim for consideration.

IASLC Regent News

IASLC Regent Profile: Southern Africa
Professor Anthony Linegar, MD, ChB, FCS, PhD

Thoracic Surgery
Cape Town, South Africa

Prof. Linegar was nominated by the South African Thoracic Society, and appointed as Regent by the IASLC Board of Directors in 2011 for the Southern African countries. There are major challenges in this area include the fact that all countries have major problems in development and sustainability of primary and tertiary level health care services.  There is very limited IASLC membership in this region. 

It remains an unfortunate fact that thoracic surgery is very underrepresented in all Southern African states due to the nature of local health service infrastructure, low levels of interest in thoracic surgery as a subspecialty, and ongoing difficulties of changing the status quo favourably. 

A positive note is that the number of foreign registrars from sub-Saharan countries outside of South Africa has steadily increased.  It is hoped that instilling an interest in thoracic surgery in these young surgeons, who must return to their home countries on completion of their training, will eventually create a groundswell of development in thoracic surgery in the Southern African continent.

The countries of South Africa, Madagascar, Botswana, Namibia, Mauritius may represent the highest opportunity for both membership and development of thoracic oncology initiatives. 

Any IASLC members with contacts in this region are encouraged to notify them about the free membership in IASLC for Fellows/Students/Trainees, and also discounted membership of only $50/annual for the countries in this region or please contact Prof. Linegar directly (  

More information on the Council of Regents 
Please invite a Fellow, Resident or Trainee today!  

IASLC MEMBERS: If you have a career or funding opportunity you would like featured in a future newsletter, please email Rob Mansheim for consideration.

This Month's Contributors:
IASLC Newsletter Editor: Anne Tsao, MD - USA

Fred R Hirsch; Tony S.K. Mok;

IASLC Newsletter Subcommittee:

Ingrid Du Rand, UK; Glenda Colburn, Australia; Geoffrey Oxnard, USA; Sai-Hong Ou, USA; Ross Soo, Singapore; Carolyn Clary-Macy, USA; Richard Booton, UK; Heather Wakelee, USA; Rob Mansheim, Staff Liaison

Are you interested in getting more involved in IASLC?  In order to meet increased communication needs, the IASLC is seeking to expand the Communications Committee. IASLC is especially interested in volunteer members who are active on social media.  Please use the online form to self-nominate for the position.  If you have questions, please don't hesitate to contact Rob Mansheim at

IASLC MEMBERS: If you have a newsworthy item or career opportunity you would like featured, please email Rob Mansheim for consideration.