Research & Education

Staging

9th Edition of the TNM Classification of Malignant Tumours

The IASLC Lung Cancer Staging Project is an international effort to study and improve the current staging system for lung cancer. Over the past two decades, the International Association for the Study of Lung Cancer (IASLC) Staging Project has been a steady source of evidence-based recommendations for the TNM classification for lung cancer published by the Union for International Cancer Control and the American Joint Committee on Cancer. The Staging and Prognostic Factors Committee of the IASLC is now issuing a call for participation in the next phase of the project, which is designed to inform the ninth edition of the TNM classification for lung cancer. Following the case recruitment model for the eighth edition database, volunteer site participants are asked to submit data on patients whose lung cancer was diagnosed between January 1, 2011, and December 31, 2019, to the project by means of a secure, electronic data capture system provided by Cancer Research And Biostatistics in Seattle, Washington. Alternatively, participants may transfer existing data sets. The continued success of the IASLC Staging Project in achieving its objectives will depend on the extent of international participation, the degree to which cases are entered directly into the electronic data capture system, and how closely externally submitted cases conform to the data elements for the project.

PROTOCOL:

The protocol document posted below is being provided to collaborating institutions so that we may standardize the collection of staging information about these patients, while ensuring that private information is gathered in compliance with applicable law and with respect and regards for human subjects.

Download the Protocol for Ethics Review and Grant Application for the third cycle of the IASLC Lung Cancer Staging Project, activated on 9 OCT 2017.

APPLICATION MATERIALS:

CRAB application materials include the CRAB Data Use Agreement, Account Request form, and Site Cohort Description Form. Additionally, an IASLC Data Use Agreement must be signed for all sites applying beginning in 2018.
Please note that the CRAB and IASLC Data Use Agreements must be signed by the appropriate site representative. A scanned image of the signed document should be submitted by email. All institutions will require access to the Electronic Data Capture (EDC) system in order to submit data to the project. Data will be entered directly into the EDC or uploaded via secure file transfer. To apply, please email the completed application materials to webhelpiaslc@crab.org.

Download the CRAB Application Materials

Download the IASLC Data Use Agreement

SUPPORTIVE DOCUMENTS:

Download the Data Elements. This document illustrates the data being collected. Last revised on 20 Jul 2018.

Download the Definitions for T, N, and M Descriptors (8th Edition)

Download IASLC 2009 Nodal Map

8th Edition of the TNM Classification of Malignant Tumours

The IASLC Staging and Prognostic Factors Committee (SPFC) proposed revisions to the lung cancer stagingsystem for the 8th edition of the TNM Classification of Malignant Tumours. The Union for International Cancer Control (UICC) and the American Joint Committee on Cancer (AJCC) accepted these revisions, and the 8th edition of the TNM Classification was implemented in January 2017. In the United States, implementation was delayed until January 2018; now, the new edition has been enacted worldwide. The objective was to further explore and analyze the impact on prognosis of tumor size and of the different T descriptors; the prognostic significance of tumor burden in hilar and mediastinal lymph nodes; and the confirmation of the revised M1 categories (M1a and M1b) of the seventh edition of the classification along with the prognostic impact of number and anatomic location of metastases.

View the available IASLC 8th Edition Staging Educational Materials

Mesothelioma Staging Project

The Prospective Malignant Pleural Mesothelioma (MPM) Staging Project is an international effort to study and improve the current staging system for MPM. This study is being conducted by the International Staging Committee of the International Association for the Study of Lung Cancer (ISC-IASLC), in collaboration with the International Mesothelioma Interest Group (IMIG). Data are being entered by means of a secure, web-based, electronic data capture system provided by Cancer Research and Biostatistics (CRAB) in Seattle, Wash., U.S.A.

View more information about the Mesothelioma Staging Project.

Thymic Malignancy Staging Project

No official thymic staging system exists, seriously hampering progress in this relatively rare tumor. The IASLC International Staging and Prognostic Factors committee is working together with the International Thymic Malignancy Interest Group to develop a data-driven stage classification system. A database of approximately 10,000 cases has been assembled with the collaborative engagement of multiple centers across the world and is currently being analyzed to accomplish this.