Lung Cancer Control and Epidemiology

Early Detection and Developing Preclinical Biomarkers
  1. Discuss the non radiographic technologies being studied for lung cancer diagnosis and potentially early detection
  2. Results of discovery and validation of these technologies


Lung Cancer Molecular Carcinogenesis

Copy Number Abnormalities and Gene Rearrangements in Lung Cancer: Present and Developing Technologies
  1. Most common chromosomal abnormalities in lung cancer
  2. How FISH and CGH can identify these abnormalities
  3. Functional implications of these abnormalities
Mutational Events in Lung Cancer: Present and Developing Technologies
  1. Techniques used for the discovery of lung cancer mutations
  2. Frequency of those mutations
  3. Molecular pathway implications of those mutations
Epigenetic Events, Alterations, and Remodeling in Lung Cancer: Present and Developing Technologies
  1. Functional implications and causes of methylation
  2. How to measure methylation
  3. Most common methylated species and the implications of methylation in lung cancer


Stem Cells and Lung Cancer: In Vitro and In Vivo Studies

  1. Describe the characterization of lung cancer stem cells
  2. Summarize current knowledge on stem cell signaling pathways and cell markers used to identify the lung cancer stem cells
  3. Review relevant in vitro and in vivo studies
Microenvironment and Lung Cancer
  1. Initiation of lung cancer carcinogenesis: role of the local environment/inflammation
  2. Discussion of how the microenvironment promotes sustained growth of lung cancer either through the cytokine release or direct cellular contact
MicroRNAs as Biomarkers for Lung Cancer
  1. Address importance of microRNAs in the diagnosis, prognostication and treatment response prediction
Humoral and Cellular Immune Dysregulation and Lung Cancer
  1. Basic immunologic discussion of abnormalities both cellular and humoral in lung cancer


Classic Anatomic Pathology and Lung Cancer
  1. Distinctions between the classical variants of non small cell lung cancer
  2. Further discuss the differences between adenocarcinoma of the lung
  3. Present pathological tools used in order to make these diagnoses
  4. Role of Immunohistochemistry
  5. Role of cytology
Molecular Testing and Lung Cancer
  1. Discussion of molecular tests which have clinical relevance at this time
  2. Discuss methods for obtaining material for testing and requirements
  3. Discuss the problems and advantages of platforms used to do these molecular tests
  4. Discuss promising new molecular markers for the future
Management of the Small Biopsy in the Molecular Era


Clinical and Radiologic Presentation of Lung Cancer

Clinical Presentation
  1. Symptoms and signs of non small cell lung cancer
  2. Symptoms and signs of small cell lung cancer
  3. Describe paraneoplastic and other syndromes associated with NSCLC
  4. Clinical and molecular methods for the prognostication of lung cancer


Diagnosis and Staging of Lung Cancer

Diagnostic Work-Up of Suspected Lung Cancer
  1. Outline of the diagnostic work-up of the patient with suspected lung cancer presenting with disease confined to the chest
  2. Role of endoscopic techniques in the diagnosis and staging of lung cancer including broncoscopy, EUS, EBUS, Superdimensions and data on accuracy of staging with these singly or in combination
  3. Role and accuracy of FNA and CORE biopsy in lung cancer
IASLC Staging System
  1. Discuss the present staging system for NSCLC, SCLC carcinoid
  2. Discuss future plans for the staging system
Statistical methods
  1. Statistical measures for diagnostic accuracy measurement
  2. Statistical measures for interrater agreement


Other Thoracic Malignancies

Malignant Mesothelioma
  1. Biology of pleural mesothelioma
  2. Biomarkers
  3. Chemotherapy
  4. Surgery
  5. Multimodality
  6. New therapies
Mediastinal Tumors
  1. Tumors other than thymoma
  2. Surgical radiotherapy and chemotherapy management
Neuroendocrine Tumors of the Lung Other than SCLC
  1. Diagnosis
  2. Surgical management
  3. Chemotherapy and targeted agents
Thymic Cancer/Thymoma
  1. Treatment options according to the stage of the disease
  2. Role of systemic therapy and radiotherapy