Research & Education

Staging

Lung Cancer Staging Project

The recently-released eighth edition of the TNM staging system is informed by a database comprising of 94,708 patients that were diagnosed around the world from 1999-2010. The objective was to further explore and analyze the impact on prognosis of tumor size and of the different T descriptors; the prognostic significance of tumor burden in hilar and mediastinal lymph nodes; and the confirmation of the revised M1 categories (M1a and M1b) of the seventh edition of the classification along with the prognostic impact of number and anatomic location of metastases.

The Second Edition of the IASLC Staging Manual in Thoracic Oncology reports on the latest revisions of the tumor, node and metastasis (TNM) classifications of thoracic malignancies, namely, lung cancer, malignant pleural mesothelioma, carcinoma of the esophagus and of the esophago-gastric junction and thymic epithelial tumors. 

The main differences of this second edition of the IASLC Staging Manual in Thoracic Oncology are:

  • It contains information on the four above-mentioned neoplasms, instead of the first edition's sole focus on lung cancer and mesothelioma
  • Besides the chapters describing the basic TNM classifications of the four thoracic malignancies, there are chapters on the history of the TNM classifications of the four tumors that give a lot of background information on the development of their staging systems
  • There are original chapters on the new recommendations proposed by the IASLC for classifying lung cancers presenting with multiple lesions, for measuring tumor size and for coding the newly described adenocarcinoma in situ and minimally invasive adenocarcinoma, as well as on prognostic factors
  • There are color atlases graphically describing the TNM classifications of the four thoracic malignancies
  • Additional chapters assist in the classification of tumors with characteristics that do not fit in the present official descriptors 

The eighth edition of the TNM staging system has been officially accepted by the Union for International Cancer Control (UICC) and the American Joint Committee on Cancer (AJCC); although, the AJCC has delayed its implementation of the eighth edition of the staging system until 2018.

The Manual is available for purchase on Amazon.

View the New retrospective and prospective databases overview

View the Protocol Document 

View the Protocol Appendix 

View the Data Elements 

View the Educational Materials

Mesothelioma Staging Project

The Prospective Malignant Pleural Mesothelioma (MPM) Staging Project is an international effort to study and improve the current staging system for MPM. This study is being conducted by the International Staging Committee of the International Association for the Study of Lung Cancer (ISC-IASLC), in collaboration with the International Mesothelioma Interest Group (IMIG). Data are being entered by means of a secure, web-based, electronic data capture system provided by Cancer Research and Biostatistics (CRAB) in Seattle, Wash., U.S.A.

View more information about the Mesothelioma Staging Project.

Thymic Malignancy Staging Project

No official thymic staging system exists, seriously hampering progress in this relatively rare tumor. The IASLC International Staging and Prognostic Factors committee is working together with the International Thymic Malignancy Interest Group to develop a data-driven stage classification system. A database of approximately 10,000 cases has been assembled with the collaborative engagement of multiple centers across the world and is currently being analyzed to accomplish this.