Featured Science and Communiqués
Combined FISH and IHC Identifies Patients with Rare ALK Fusions that Respond to Crizotinib
DENVER – The combined use of fluorescence in situ hybridization (FISH) and immunohistochemistry (IHC) identified non-small cell lung cancer (NSCLC) patients with rare or novel anaplastic lymphoma kinase (ALK) gene rearrangements, not otherwise identified by FISH alone, that showed response to crizotinib treatment.
Lymph Node Stage May Have Clinical Significance Among NSCLC Patients with Stage IV M1a Disease
DENVER – Analysis of a large non-small cell lung cancer (NSCLC) patient cohort with stage IV M1a disease identified lymph node staging as having clinical significance and an impact on prognosis.
Leptomeningeal Metastases Are More Common in NSCLC Patients Harboring EGFR Mutations and Respond Positively to TKI Therapy
DENVER – Leptomeningeal metastases (LM), a devastating complication and predictor of poor survival in lung cancer patients, was found to be more prevalent in non-small cell lung cancer (NSCLC) patients with epidermal growth factor receptor (EGFR) mutations. Patients receiving tyrosine kinase inhibitors (TKIs) targeting EGFR mutations had a longer overall survival (OS) than those who did not receive TKIs, demonstrating the effectiveness of TKIs for LM therapy.
Liquid Biopsies for the Identification of EGFR Mutations and for the Prediction of Lung Cancer Recurrence
DENVER – Three manuscripts published in the recent issue of the Journal of Thoracic Oncology, the official journal of the International Association for the Study of Lung Cancer (IASLC), explored the versatility of liquid biopsies by identifying EGFR mutations using circulating tumor DNA (ctDNA) in urine and plasma and examining circulating tumor cells (CTCs) in plasma to predict the risk of lung cancer recurrence after surgical resection. Collectively, these findings illustrate the potential and reach of liquid biopsies in both identifying patients suitable for targeted treatment as well as predicting cancer recurrence.
IASLC News
- September 26, 2016
IASLC Supports Mesothelioma Awareness Day
Meet Our Members
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Michael Boyer, MBBS, PhD
Sydney Cancer Center, Australia
Silvia Novello, MD, PhD
San Luigi Hospital, University of Turin, Italy -
Gerard Silvestri, MD, MS
Division of Pulmonary and Critical Care, Medical University of South Carolina, Charleston, South Carolina
Sumitra Thongprasert, MD
Chiang Mai University, Thailand -
Yi-Long Wu, MD
Guangdon Lung Cancer Institute, Guangzhou, PR China
Solange Peters, MD, PhD, PD-MER
University of Lausanne, Lausanne, Switzerland -
Heather Wakelee, MD
Associate Professor of Medicine, Oncology Stanford University , Stanford, California
Pasi A. Jänne, MD, PhD
Dana Farber Cancer Institute, Boston, Massachusetts -
Fred R. Hirsch, MD, PhD
University of Colorado School of Medicine, U.S.A.
Laurie Gaspar, MD, MBA, FASTRO, FACR
University of Colorado , Denver, Colorado -
Tony Mok, MD
Chinese University of Hong Kong, China
Gail Darling, MD, FRCSC, FACS
University of Toronto, University Health Network , Toronto, Ontario Canada -
Tetsuya Mitsudomi, MD, PhD
Aichi Cancer Center Hospital , Japan
Khaled Alkattan, FRCS
King Faisal Hospital, Alfaisal University, Riyadh, Saudi Arabia -
Francoise Mornex, MD, PhD
University Claude Bernard, Lyon, France
Purvish Parikh, MD, DNB, FICP, PhD, ECMO, CPI, MBA
Indian Cooperative Oncology Network, Mumbai, Mahrashtra, India -
Hisao Asamura, MD
National Cancer Center Hospital, Japan
David Carbone, MD, PhD
The Ohio State University, U.S.A. -
Yuichiro Ohe, MD
National Cancer Center Hospital East, Chiba, Japan
Paul A. Bunn, Jr., MD
University of Colorado School of Medicine, U.S.A. -
Rolf Stahel, MD
University Hospital Zurich, Switzerland
Dato'D Mohamed Ibrahim Wahid, DPMP, MB, Bch, DMRT, Am
Beacon International Specialist Centre, Selangor, Malaysia -
Kazuhiko Nakagawa, MD, PhD
Kinki University Faculty of Medicine, Japan
Erik Jakobsen, MD, MPM
Chief Surgeon, Manager of the Danish Lung Cancer Registry, Odense, Denmark -
Eduardo Richardet, MD, PhD
Cordoba Oncology Institute, Cordoba, Argentina
Hak Choy, MD
UT Southwestern Medical Center, U.S.A. -
Johan Vansteenkiste, MD, PhD
University Hospitals Leuven, Belgium
Shuji Sakai, MD, PhD
Department of Diagnostic Imaging and Nuclear Medicine, Shinjuku-ku, Tokyo, Japan -
Deniz Yalman, MD, PhD
Professor, Department of Radiation Oncology, Izmir, Turkey
Mauro Zamboni, MD, FCCP, MsSc
National Cancer Institute, Rio de Janeiro, Brazil -
Debra Violette, Founder and President
Free ME from Lung Cancer, Non-profit organization, Maine
Keith Kerr, BSc, MB, ChB, FRCPath, FRCPE
University of Aberdeen, Aberdeen, Scotland -
Kwun Fong, MBBS, FRACP, PhD
The Prince Charles Hospital, Australia
David Gandara, MD
UC Davis Comprehensive Cancer Center, U.S.A. -
Karen Kelly, MD
UC Davis Comprehensive Cancer Center, U.S.A.
William D. Travis, MD
Memorial Sloan Kettering Cancer Center, New York, New York -
Jong Jo Park, MD, PhD
Korea Cancer Center Hospital, Seoul, Korea
Dominique Grunenwald, MD, PhD
Hospital Tenon, University of Paris, France -
Nick Pavlakis, MBBS, MMed, PhD, FRACP
Royal North Shore Hospital, Sydney University, St. Leonards, (Sydney), NSW, Australia
Keunchil Park, MD, PhD
Samsung Medical Center, Sungkyunkwan University School of Medicine, South Korea -
Anne Tsao, MD
University of Texas M.D. Anderson Cancer Center, Houston, TX
Journal of Thoracic Oncology
The IASLC’s premier journal, emphasizing a multidisciplinary approach including original research (clinical trials and translational or basic research), reviews and opinion pieces.
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