Radiotherapy Challenges in Locally Advanced Non-Small Cell Lung Cancer in the Neoadjuvant Era

Stage III NSCLC is now a moving target! This webinar will address key practice gaps and real-world decision points in the radiotherapy management of locally advanced (Stage III) non-small cell lung cancer in the era of neoadjuvant chemo-immunotherapy and evolving multimodality care. Through three focused talks and case-based discussion, the session will explore:

1. Contemporary mediastinal staging, integrating PET/CT and invasive nodal assessment, interpreting discordant findings, and understanding how staging quality directly influences treatment intent and radiotherapy volumes
2. Practical strategies for patients who begin neoadjuvant chemo-immunotherapy but do not proceed to surgery;  how to redefine intent, and transition efficiently to definitive radiotherapy/chemoradiotherapy while mitigating pulmonary and immune-related toxicities
3. When and how to deliver post-operative radiotherapy after neoadjuvant chemo-immunotherapy with a risk-adapted framework based on margin status and residual nodal disease, optimize target delineation with modern techniques, and coordinate sequencing with systemic therapy. By bringing pragmatic principles of radiation therapy together, the webinar aims to reduce variability in practice and support clinicians in delivering evidence-based, quality care.